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KMID : 0614620220800060247
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Korean Journal of Gastroenterology
2022 Volume.80 No. 6 p.247 ~ p.253
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Treatment of Acid-related Diseases Using Potassium-competitive Acid Blockers
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Choi Yoon-Jin
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Abstract
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Proton pump inhibitors (PPIs) have several limitations to their efficacy including insufficient acid suppression, slow onset of action, and variable efficacy among patients due to CYP2C19 metabolism. Potassium-competitive acid blockers inhibit H+-K+-ATPase in a reversible and K+-competitive manner, are novel acid suppressive drugs with rapid onset of action, meal independence, and prolonged control of intragastric acidity compared to PPIs. Potassium-competitive acid blockers exhibited non-inferior therapeutic efficacies on reflux esophagitis, gastric ulcers, and Helicobacter pylori eradication. The review is focused on the unmet needs across the acid-related diseases and recent updates on clinical studies using vonoprazan and tegoprazan.
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KEYWORD
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Gastric acid, Gastroesophageal reflux, Peptic ulcer, Helicobacter pylori
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